The presence of criteria aPL (LA, aCL, and aβ2GPI) was not found to be associated with the IFN-I pathway activation in any of the APS subsets (Supplementary Table S2), but when computed in terms of the aPL profile, triple aPL positivity was associated with enhanced IFN-I pathway activation only in aPL carriers (IFN score: p = 0.050), although differences were found among ISGs (Supplementary Table S3). The gene discussed is IFNA1; the disease is autoimmune polyendocrinopathy.