On the other hand, it can simultaneously inhibit the degradation of NPs, such as A-type NPs (ANPs), B-type NPs (BNPs), and C-type NPs (CNPs) through enkephalinase leading to increased levels of cyclic guanosine monophosphate and reduced cardiac remodeling in patients with heart failure (HF) [13–17]. Here, MME is linked to hydrops fetalis.