NR1H2 and colorectal carcinoma: In another study, the LXRβ was reported to interact with Pannexin-1 (Panx1) which usually activates the P2X7 receptors (P2X7R) and triggers cell death, that induced pyroptosis in caspase-1-dependent manner in CRC (Derangère et al., 2014; Loureiro et al., 2022).