Some studies reported that in viruses-induced HCC, the HCV core protein, non-structural protein 5A, and HBV X protein were degraded which was mediated by sterol-regulatory-element-binding protein overexpression in LXRα/RXRα-dependent pathway (Moriishi et al., 2007; Lima-Cabello et al., 2011). Here, NR1H3 is linked to hepatocellular carcinoma.