Captivatingly, a natural steroidal lactone Withaferin A isolated from Withania somnifera acts as a LXRα agonist, and inhibits the expression of various transcriptional targets such as serpin F1, Angiogenin, Endothelin-1, PAI-1, and ICAM-1 in HCC and even inhibits its proliferation, angiogenesis and migration (Shiragannavar et al., 2020; Shiragannavar et al., 2022; Shiragannavar et al., 2023). This evidence concerns the gene NR1H3 and hepatocellular carcinoma.