ANG and hepatocellular carcinoma: Withaferin A isolated from Withania somnifera was identified as a novel LXR agonist that inhibits NF-κB, downregulates PEDF, Angiogenin and ICAM-1, induces the expression of ABCA1, ABCG1, and Apolipoprotein (ApoE) levels and thus inhibits the proliferation of HCC cells in vitro (Shiragannavar et al., 2020).