Collectively in HCC, mostly activated LXRα (LXRβ was not much reported) plays a crucial role by regulating the transcriptional targets, inhibiting the cell cycle regulators, epigenetic regulation of lncRNA/miRNA/mRNA axis, and inducing apoptosis and inhibiting cell proliferation, differentiation and migration. The gene discussed is NR1H3; the disease is hepatocellular carcinoma.