AKT1 and acute myeloid leukemia: In acute myeloid leukemia and T-acute lymphoblastic leukemia cells, the T0901317 and GW3965 mediate the cholesterol efflux by upregulating the expression of ABCA1 and ABCG1, and downregulating the expression of LDLR and VLDLR levels; promoting apoptosis; inhibited proliferation, inhibited NF-κB activation, inhibits the IL-3–induced signaling pathway thereby by inhibits the phosphorylation of STAT5 and Akt in AML cells (Ceroi et al., 2016).