BCL2 and B-cell chronic lymphocytic leukemia: Geyeregger R et al., reported that the LXR agonists T0913017 and GW3965 inhibit the phosphorylation of cyclin B, cyclin D3, cyclin E; inhibit the IL-2-induced proliferation and induce cell cycle arrest at G1/S phase and G2/M phase; promotes apoptosis; inhibits the expression of bcl-2 and MMP-9 genes in Kit225 T-CLL cells, T cell blasts from healthy donors, and primary T and B cells from CLL patients respectively (Geyeregger et al., 2009).