When combined with gefitinib, T0901317 reduced the migration and invasion levels of lung cancer via inhibition of the MAPK pathway (Lou et al., 2019), and sensitized the HCC cells towards sorafenib by inhibiting Mesenchymal-Epithelial Transition (MET) and EGFR (Shao et al., 2020). The gene discussed is EGFR; the disease is hepatocellular carcinoma.