In contrast, T0901317 activated LXRα inhibits alpha-smooth muscle actin or α-SMA (ACTA2) and negatively regulates the TGFβ differentiation in HCC resulting in the increase in the fatty acid synthase (FASN) expression levels the inhibition of tumour growth (Morén et al., 2019). This evidence concerns the gene NR1H3 and hepatocellular carcinoma.