T0901317 exhibited synergistic in combination with vitamin D3 by increased expression of ABCA1 levels and reduced expression of cholesterol levels, and significantly promoted apoptosis by upregulating BAX and downregulating Bcl-2 levels in MCF-7 cells and thus observed to prevent hyperlipidemia-mediated estrogen receptor-positive (ER+) BC progression (Munir et al., 2020). The gene discussed is ESR1; the disease is breast cancer.