Withaferin A isolated from Withania somnifera was identified as a novel LXR agonist that inhibits NF-κB, downregulates PEDF, Angiogenin and ICAM-1, induces the expression of ABCA1, ABCG1, and Apolipoprotein (ApoE) levels and thus inhibits the proliferation of HCC cells in vitro (Shiragannavar et al., 2020). This evidence concerns the gene NFKB1 and hepatocellular carcinoma.