They also investigated associations between fibrinolysis impairment and adverse outcomes in sepsis patients and reported higher SOFA scores, mortality, and longer ICU stays in patients classified as “low responders” to urokinase.21A recent paper by the ISTH SSC (Scientific and Standardization Committee) subcommittee on fibrinolysis by Scarlatescu et al23evaluated the utility of t-AUCi parameter (time between MaxV and maximum clot formation) in ROTEM® with different concentrations of tPA. Here, PLAT is linked to Sepsis.