Furthermore, the new model, which involved adding NAR after r-tPA treatment to the conventional model (including age, gender, admission NIHSS scores, hypertension, hyperlipidaemia and atrial fibrillation), was found a statistically significant improvement in discriminatory power and risk reclassification for 3-month poor outcomes in AIS patients treated with r-tPA. The gene discussed is PLAT; the disease is hyperlipidemia.