COL17A1 and bullous pemphigoid: Indeed, it seems that people suffering from degenerative pathologies, such as Alzheimer's, are 10 times more prone to develop bullous pemphigoid because BPAG2, also called BP-180, is present both in basal keratinocytes and in the CNS, notably in the basal nucleus and hippocampus where Alzheimer's lesions have been observed.