Conversely, for patients with benign lung lesions, CEA (P <0.001), NSE (P=0.001), GRP (P=0.013), and age (P <0.001) were influential factors in lung cancer screening, whereas sex (P=0.81), CA125 (P=0.22), and CY211 (P=0.33) did not significantly impact the screening of patients with benign lung lesions. Here, ENO2 is linked to lung cancer.