RRM2B and colorectal carcinoma: There was no significant difference in the luciferase activity of the RRM2B promoter between sh-control and sh-METTL3 cells (Fig. S3F), suggesting that METTL3 does not affect the transcription of RRM2B. This was further confirmed using qRT–PCR analysis, which showed comparable levels of the precursor mRNA of RRM2B between sh-control and sh-METTL3 CRC cells (Fig. S3G).