PLS3 and osteoporosis: ,9 In this context, it has been shown that mutations in Plastin 3 (PLS3) are causative for BMD quantitative trait locus 18, BMND18; (MIM 300910), a monogenic X-linked, early-onset osteoporosis development in men and postmenopausal women, where the number of PLS3 mutations identified is continuously rising.10