The robust anti-inflammatory effect of CHF6297 was also confirmed in another model of acute pulmonary inflammation induced by the instillation of IL-1β, a proinflammatory cytokine associated with inflammasome activation and elevated during acute COPD exacerbations (Kubysheva et al., 2022), as well as during the hyperinflammatory response occurring in severe acute respiratory syndrome driven by SARS-CoV-2 (Gilroy et al., 2021). Here, IL1B is linked to chronic obstructive pulmonary disease.