Based on a comprehensive review of the literature, previous results from enrichment analysis, and PPI data, we validated five co-upregulated genes (DGAT1, AMOT, PDE11A, TYMS, and TMEM98) and six co-downregulated genes (FOS, PTGS2, SOCS3, ZFP36, TLR2, and BTG2) in the blood samples of patients from four groups: HC, AF, NAFLD, and NAFLD-AF. Here, PDE11A is linked to atrial fibrillation.