WNT3A and Alzheimer disease: According to the many studies on AD and a few studies on VaD, there are many cases in which it is reported that the inhibitory phosphorylation of the GSK3β protein is decreased and the canonical Wnt signaling or the expression of Wnt3a is decreased in animal models; many published studies show that the regulation of these two proteins is necessary (Zhang et al., 2016; Guo et al., 2019; Kumar et al., 2019; Zhao et al., 2019; Sayas and Ávila, 2021; Wang et al., 2021; Chauhan et al., 2022; Kumari et al., 2022; Yang et al., 2022).