Multivariable logistic regression analysis showed that pSUVmax (OR = 1.136, 95%CI 1.080–1.196, p < 0.001), tumor statement (OR = 1.331, 95%CI 1.075–1.648, p = 0.009), nodal involvement (OR = 1.590, 95%CI 1.294–1.952, p < 0.001), CEA (OR = 1.009, 95%CI 1.002–1.016, p = 0.017), and grade of TMs (OR = 2.883, 95%CI 1.884–4.411, p < 0.001) were independently associated with distant metastasis of de novo lung adenocarcinoma (Table 2). This evidence concerns the gene CEACAM5 and neoplasm.