Also, in a former study using ectopic expression of LXRα or LXRβ in an LXR‐deficient background macrophage model, we demonstrated non‐overlapping transcriptional actions of each receptor beyond fatty acid and sterol metabolism.[25] Since LXRα plays a singular role in the protection against infections,[22, 23] we focused our interest on the regulation of Nr1h3 gene transcription (for clarity with the nomenclature, we will use Lxrα for the gene/mRNA and LXRα for the protein) and LXRα protein expression in macrophages activated by microbial ligands. Here, NR1H3 is linked to infection.