TNF and periodontitis: For example, chemically modified curcumin (CMC 2.24) can inhibit periodontitis-related bone resorption in experimental animals; inhibit osteoclast formation; reduce the infiltration of polynuclear cells and monocytes; decrease the degradation of periodontal collagen fibers; and decrease the levels of IL-1β, IL-6, TNF-α, and matrix metallopeptidase 9 (MMP-9) [38].