Patients in the high-MRP group had a tendency to display to the known high risk molecular subtypes (T-ALL, BCR::ABL1, KMT2A-r, hypodiploid, and MEF2D-r), while low-risk molecular subtypes (HeH, ETV6::RUNX1, and PAX5-alteration) were more frequent in the low-MRP group. The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.