We noted a poorer prognosis in CRC patients with high ERα expression compared to the patients with low ERα expression (Fig. 1), which could be due to the significant correlations between ERα and both CysLT1R and β-catenin, all known tumour promoters [18, 20, 25, 28, 32, 35]. The gene discussed is ESR1; the disease is colorectal carcinoma.