In addition to some known variants in genes already known to be associated with neuropathy such as GDAP1, GARS1, DNM2, MFN2, SACS, C12orf65, SPG7, SDHA, PDHA1, and MT-ATP6, we detected some variants in unexpected genes such as DNA2, NDUFS6, ETFDH, SDHA, DARS2 and UCHL1, and MT-TK highlighting that neuropathy presents more widely in mitochondrial disease. The gene discussed is SACS; the disease is neuropathy.