A low-frequency (AF = 0.9%) deletion of part of exon 6 of the RGL3 gene was associated with lower blood pressure (BP) (−0.11 ± 0.01 s.d.; P = 6.1 × 10−23) and decreased hypertension risk (odds ratio (OR) = 0.86 (0.82–0.90); Fig. 3a,b and Supplementary Table 3) as well as decreased serum calcium (−0.08 ± 0.01 s.d.; P = 6.0 × 10−11; Supplementary Data 2). This evidence concerns the gene RGL3 and hypertensive disorder.