RASA4 and type 2 diabetes mellitus: The total number of copies of RASA4 carrying the Y731C missense PSV (typically ranging from 0 to 3 per individual; Fig. 4d) was associated with increasing T2D risk and ‘eveningness’ (that is, later preferred bedtime and rising time) (Fig. 4e), with a 1.30-fold (1.21–1.39) range in odds of T2D.