These cultures were subsequently infected with CCHFV.Knockout of LDLR using two different mutantiPSC clones resulted in a significant reduction in CCHFV infections, detected at1 and 3 days post infection (Fig. 4b).These data show that LDLR is also an important factor for CCHFV infections ofhuman blood vessels. This evidence concerns the gene LDLR and infection.