To investigate whether LDLR is a receptor for clinical isolates ofCCHFV, we isolated and cultured a CCHFV from a Turkish patient sample.Consistent with the results using the laboratory strain IbAr10200, addition ofsLDLR, but not sVLDLR, reduced the infection of human cells exposed to theclinical CCHFV isolate in a dose-dependent fashion (Extended Data Fig.6a,b). The gene discussed is LDLR; the disease is infection.