In contrast, six genes known to inhibit cell proliferation and tumor growth were overexpressed in d-HGP: SIRT6, MPC2, MIR4458HG, ST20-AS1, SREBF2, MRPL40 (Fig. 2b; Supplementary Fig. 5; Supplementary Tables S5, S6). The gene discussed is MIR4458HG; the disease is neoplasm.