C9orf72 and amyotrophic lateral sclerosis: While post-mortem tissues of C9orf72-ALS/FTD patients contain GR-positive aggregates, whose abundance varies in different brain regions42, we found that Kapβ2 protein expression levels were not changing, as determined by a western blot analysis of homogenates obtained from the motor cortex of C9orf72-ALS/FTD and non-diseased control cases (Fig. 1g, h; Supplementary Fig. 8).