APOE and Brain atrophy: A longitudinal study using data from the Framingham Offspring Study found no significant association between elevated serum hs-CRP levels and brain atrophy after multivariable adjustment (adjustment factors: age, sex, time to MRI scan, educational history, and APOE ε4 carrier status), and elevated serum hs-CRP levels were significantly associated with temporal lobe atrophy in APOE ε4 carriers18.