In contrast to Casp8−/−Ripk1−/−Trif−/−Zbp1−/− mice, which largely survive to adulthood but then develop lymphadenopathy that is characteristic of caspase-8 deficiency [14], Casp8−/−Tnfr1−/−Trif−/−Zbp1−/− pups exhibited stunted growth and were typically euthanized owing to ill health between 5 and 7 weeks of age (Fig. 6d, e). The gene discussed is CASP8; the disease is Lymphadenopathy.