CASP8 and Lymphadenopathy: Splenomegaly in Casp8−/−Tnfr1−/−Trif−/−Zbp1−/− mice (Fig. 6h) reflected extramedullary hematopoiesis rather than an accumulation of B220+CD3+ T cells (Fig. 6f, i, j), the latter underlying splenomegaly and lymphadenopathy in older Casp8−/−Ripk3−/− or Casp8−/−Mlkl−/− mice [22].