DES and cardiomyopathy: Mutations in the αB-Cry gene can alter its structural properties and lead to distinct clinical phenotypes, including isolated cataracts, myofibrillar myopathy, cardiomyopathy, skeletal and cardiac muscle disorders (such as desmin-related myopathies (DRM), dilated (DCM), and restrictive (RCM) cardiomyopathies), or a multi-systemic disorder that combines these features9.