The plasma proteins that are significantly associated with obesity are secreted in different tissues or organs such as in adipose tissue (LEP, FABP4) or liver (ADH4, IGFBP1), these findings may further the understanding mechanisms linking obesity and impaired metabolic health with a focus on organ cross-talk36–38. The gene discussed is IGFBP1; the disease is obesity due to melanocortin 4 receptor deficiency.