LRRK2 and Parkinson disease: They found that the medial orbitofrontal region shows key distinctions between all familial PD or pure leucine-rich repeat kinase 2 familial PD and nonmanifest carriers, as well as between PD and non-PD, emphasizing a potentially significant contribution of PVS to the pathophysiology of familial PD, particularly leucine-rich repeat kinase 2.