Although, 753b was efficient in degrading both BCL-xL and BCL-2 and inducing apoptosis in AML cells36, based on our cellular studies WH244 was more potent in killing Jurkat cancer cells (also dependent on BCL-xL/BCL-2) as compared to other SMIs, DT2216 and 753b (Fig. 3g). Here, BCL2 is linked to acute myeloid leukemia.