Given that M. tuberculosis-secreted protein EsxB inhibits the p38 phosphorylation-dependent LLPS of METTL14, thereby reducing the m6A RNA methylation and mRNA stability of Nox2, which reduces ROS levels and increases intracellular survival of M. tuberculosis (Fig. 8a), we next investigated whether this regulatory mechanism or target is clinically associated with human tuberculosis caused by M. tuberculosis. Here, CYBB is linked to tuberculosis.