Although the intracellular survival of M. tuberculosis markedly decreased in control macrophages that were infected with all these mutant strains (Fig. 1b; Supplementary Fig. S1i, j), only the lower survival of H37Rv:ΔEsxB was restored in macrophages whose Mettl14 gene was knocked down or knock out (Fig. 1c–e; Supplementary Fig. S1i, k) at 24 h post infection. The gene discussed is METTL14; the disease is infection.