Consistently, knockout of Mettl14 in macrophages also increased the intracellular bacteria CFU count at 24 h post-infection (Fig. 1a), while no significant difference in CFU count was observed between mMettl14f/f and mMettl14−/− at 2 h post-infection suggesting that the macrophages isolated from mMettl14−/− mice may have a deficiency in limiting intracellular M. tuberculosis. Here, METTL14 is linked to infection.