METTL14 and tuberculosis: Compared with mMettl14f/f mice, mMettl14−/− mice infected with M. tuberculosis exhibited a significant increase in bacterial burden (increased ~1.45 fold in log10 at day 30; increased ~2.23 fold in log10 at day 60) and histological damage in the lungs, supporting the essential role of METTL14 in host anti-TB immunity on controlling M. tuberculosis bacterial loads in vivo (Fig. 8b–e).