Next, to determine if autocrine and/or paracrine MIF signaling may be involved in our experimental models, we analyzed by FACS the expression of MIF receptors CD74, CD44 and CXCR4 on primary AML blasts (Fig. S1B) and MΦ (Fig. S1C) from newly diagnosed patients, as well as on M-MΦ (activated by M-CSF), on CM-MΦ (activated by AML conditioned medium, CM), and on reprogrammed MΦ (R-MΦ) (Fig. S1D). Here, CSF1 is linked to acute myeloid leukemia.