At the end of the experiment, FC analyses of fresh bone marrow (BM) extracted from long bones showed that AML burden was significantly reduced in 4-IPP ± GM-CSF treated mice, as determined by the proportions of GFP+ humanCD45 + U937.GFP-FFLuc AML cells, while GM-CSF alone had no effect, like vehicle (Fig. 5B). The gene discussed is CSF2; the disease is acute myeloid leukemia.