Aberrant glycosylation in the TME has been associated with ECM remodeling, cellular interactions, antigen-antibody recognition, inflammation, and immune surveillance and responses.2 A highly glycosylated protein, SEMA7A is involved in angiogenesis, liver fibrosis, neurogenesis, dendritic cell migration, and breast and pulmonary cancer progression.19,20,26,27,29 However, the functional role of SEMA7A glycosylation has not been reported, especially in tumor progression. The gene discussed is SEMA7A; the disease is neoplasm.