FUT8 and head and neck squamous cell carcinoma: We show that the fucosyltransferase FUT8 catalyzes aberrant core fucosylation in SEMA7A at N-linked oligosaccharides (Asn 105, 157, 258, 330, and 602) via a direct protein‒protein interaction, an action that is necessary for SEMA7A trafficking from the cytoplasm to the cytomembrane and indispensable for HNSCC progression.