Through GO and KEGG analyses of the HNSCC database from the cancer genome atlas (TCGA-HNSCC), we discovered that a high abundance of SEMA7A was associated with extracellular matrix (ECM) organization and ECM receptor interaction, indicating that SEMA7A participated in tumor microenvironment remodeling (Fig. 7a, b). Here, SEMA7A is linked to head and neck squamous cell carcinoma.