Through RNA-Seq analysis of HNSCC samples (3 tumors and 3 para-carcinoma tissues), we identified 8 pivotal marker genes (PCDH7, CDH2, ITGA3, SEMA7A, TMEM132A, CD276, TMEM2, GPR158) that were overexpressed in tumor specimens (Supplementary Fig. 1a, Supplementary Table 1). The gene discussed is GPR158; the disease is head and neck squamous cell carcinoma.