Through RNA-Seq analysis of HNSCC samples (3 tumors and 3 para-carcinoma tissues), we identified 8 pivotal marker genes (PCDH7, CDH2, ITGA3, SEMA7A, TMEM132A, CD276, TMEM2, GPR158) that were overexpressed in tumor specimens (Supplementary Fig. 1a, Supplementary Table 1). This evidence concerns the gene TMEM132A and head and neck squamous cell carcinoma.