SEMA7A and neoplasm: SEMA7A, also named CD108w, belongs to the Semaphorin family; it contains two cell surface receptors composed of integrin β1 and α1 or αV subunits and plexinC1, and is well known for its role in angiogenesis, olfactory nerve outgrowth and the immune response.19–24 The association of SEMA7A with oncogenesis and tumor progression has been increasingly clarified.