ATG16L1 and Crohn disease: The autophagy-deficient ATG16L1 T300A variant also impacts CD4+ T helper cell responses in individuals suffering from Crohn’s disease and has been associated with concomitant loss of regulatory T-cell (Treg) responses and increased frequencies of inflammatory Th1 and Th17 cells in murine intestines21,22, underscoring the significance of functional autophagy in curbing Th17-mediated inflammatory disorders.