ATG16L1 and AIDS: Univariate Cox regression survival analysis for the remaining five ATG16L1 SNPs revealed a significant protective effect for two ATG16L1 SNPs (rs6861 and rs7563345) using AIDS diagnosis (Center for Disease Control [CDC] 1987) as endpoint, and for four ATG16L1 SNPs (rs2241880, rs6861, rs3792106 and rs7563345) using AIDS-related death as endpoint (Fig. 1d).