Digital ulceration (OR 1.6; 95% CI: 1.3, 1.9; P < 0.01), raised CRP (OR 1.4; 95% CI: 1.1, 1.7; P = 0.01) and PAH (OR 2.0; 95% CI: 1.4, 3.0; P < 0.01) were associated with increased risk of malnutrition. The gene discussed is CRP; the disease is malnutrition.