The results demonstrated the following distribution in the examined tissues: among 20 cases of Normal Skin Tissue (NT), there were no cases of strong positive, positive, weak positive, or negative SIRT6 expression; for 60 cases of AK tissue, the distribution was 3-cases, 31-cases, 22-cases, and 4-cases, respectively; in 25 cases of BD tissue, the distribution was 9-cases, 14-cases, 2-cases, and 0-cases, respectively; and among 70-cases of CSCC tissue, there were 46-cases, 18-cases, 6-cases, and 0-cases, respectively (Fig. 1B). Here, SIRT6 is linked to Behcet disease.