At their OGD LD50, endothelial cells significantly altered expression of stroke pathway genes related to fibrinolysis (increased plasminogen, decreased serpin E-1), genes related to vasodilation (leptin, cyclooxygenase 2, amyloid precursor protein), genes related to inflammation (increased prothrombin, decreased interleukin-6 and hemoxygenase 1), and genes related to structure of the BBB (increased occludin). This evidence concerns the gene PLG and stroke disorder.