KSR1 and hearing loss disorder: MAPK signaling has been implicated in cisplatin- and noise-induced hearing loss (Lahne and Gale, 2008; Herranen et al., 2018; Ingersoll et al., 2020; Ingersoll et al., 2023; Lutze et al., 2023), and here we show that the KSR1 KO mice do not have cochlear structural abnormalities and exhibit normal hearing before damage.