Remarkably, the expression of the activated forms of the multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) was recently reported to confer RGC neuroprotection in mouse models of optic nerve injury, glaucoma, and NMDA excitotoxicity at a level not seen before in animal models (Guo et al., 2021). The gene discussed is CAMK2G; the disease is glaucoma.