SPIN1 and myeloid sarcoma: Seroconverted OCR-treated patients with MS had received fewer anti-CD20 treatments and had a longer interval between their last treatment and the initial vaccination, which was associated with reduced levels of circulating OCR as also observed previously.16 40 41 Our study is the first to perform in-depth immune profiling on circulating immune cell compartments before initial vaccination, but was unable to identify a factor that could be used to predict a patient’s ability to generate an anti-RBD IgG antibody response.