Since WDR5 cooperates with MYCN to activate a canonical MYC target gene program that fuels cell proliferation while G9a cooperates with MYCN to repress a neuronal differentiation gene program that puts a brake on differentiation, the combined targeting of WDR5 and G9a simultaneously antagonizes these MYCN-mediated gene regulatory programs to synergistically suppress NB cell proliferation. Here, MYC is linked to neuroblastoma.