WDR5 and cancer: Of note, the WDR5 or G9a dependency was not dependent on MYCN amplification status (S7E Fig), which is possible due to the high expression of c-Myc in MYCN non-amplified NB cell lines [48], while WDR5 and G9a have been shown to mediate c-MYC function in the other types of cancers [40,42].