At 24 h post-CIDR removal, 20 over-represented canonical pathways were identified (S5 Table) and the top pathways were HIF1α signaling, Axonal guidance signaling, Amyotrophic lateral sclerosis signaling, Hepatic fibrosis/hepatic stellate cell activation, and Clathrinid-mediated endocytosis signaling. This evidence concerns the gene HIF1A and amyotrophic lateral sclerosis.