Besides ODC and SMS, Spermidine/Spermine N1-acetyltransferase 1 (SAT1), the polyamine catabolic enzyme that catalyzes the acetylation of spermine and spermidine to N1-acetylspermine and N1-acetylspermidine, respectively, plays an important role in cancer progression. The gene discussed is ODC1; the disease is cancer.