Based on the strong link between NLRP3 inflammasome activation and GBM cell metastasis, the results suggest that RSV inhibits the expression of NLRP3 and its downstream inflammatory factors by JAK2/STAT3 signalling pathway, suppresses the proliferation of GBM cells while promoting their apoptosis, and exerts an inhibitory effect on GBM cell invasion and migration. This evidence concerns the gene STAT3 and glioblastoma.