JAK2 and glioblastoma: Based on the strong link between NLRP3 inflammasome activation and GBM cell metastasis, the results suggest that RSV inhibits the expression of NLRP3 and its downstream inflammatory factors by JAK2/STAT3 signalling pathway, suppresses the proliferation of GBM cells while promoting their apoptosis, and exerts an inhibitory effect on GBM cell invasion and migration.