IGFBP4 and neoplasm: The expression of selected stromal genes representing different regulatory patterns is shown in Supplemental Figure 6, B and C. We note that changes in some of the stromal genes could have contributed to the inhibition of tumor growth in castrated mice, such as upregulation of Igfbp4 (53), Ccdc80 (54), and Dlk1 (55) and downregulation of Ramp3 (56) and Osm (57).