The expression of all other Mediator kinase module components, CCNC, MED12, MED13, and MED13L (MED12L isoform is expressed at a very low level in PCa), increased from normal to primary to metastatic PCa (although the increases from normal to primary for MED13 and from primary to metastatic for MED12 did not reach statistical significance) (Figure 1E). This evidence concerns the gene MED12 and posterior cortical atrophy.