CDK8 and posterior cortical atrophy: Differences in the expression of this set of genes in 22Rv1 tumors with or without MKI correlated with changes in their expression between mCRPC relative to normal prostate, mCRPC relative to primary PCa, and primary PCa relative to normal prostate tissues (Figure 9, A–C), indicating that the effects of CDK8/19 on gene expression are increased during prostate carcinogenesis and the progression of PCa to mCRPC.