Interestingly, ETV6 and FOSL2, 2 of 6 genes identified in AML as associated with super-enhancers, hyperactivated by MKI, and inhibiting cell proliferation when overexpressed (13), were also upregulated by Mediator kinase inactivation in 22Rv1 tumors in castrated mice (Supplemental Figure 4C). The gene discussed is ETV6; the disease is acute myeloid leukemia.