FOSL2 and acute myeloid leukemia: Interestingly, ETV6 and FOSL2, 2 of 6 genes identified in AML as associated with super-enhancers, hyperactivated by MKI, and inhibiting cell proliferation when overexpressed (13), were also upregulated by Mediator kinase inactivation in 22Rv1 tumors in castrated mice (Supplemental Figure 4C).