DKK1 and neoplasm: In the much larger category of genes that are induced by castration and hyperinduced when castration is combined with MKI (Supplemental Figure 4B), we note an AR-regulated WNT protein, WNT7B (50), and the WNT inhibitor DKK1 (51), as well as annexin ANXA3 and LFNG, a gene implicated in tumor suppression in PCa (52).