Several stromal genes upregulated by MKI were shown to have tumor-suppressive effects in the stroma (Igfbp4 [ref. 53], Ccdc80 [ref. 54], Dlk1 [ref. 55]), and some downregulated genes were reported to have tumor-supporting activities (Ramp3 [ref. 56], Osm [ref. 57]). This evidence concerns the gene IGFBP4 and neoplasm.