SORD and posterior cortical atrophy: Among the genes upregulated by castration but downregulated by MKI, we note PCa biomarkers PSCA (47) and FMOD (48), whereas genes such as SORD (an androgen-responsive gene; ref. 49) and ENSG00000289695 are downregulated both by castration and by MKI (Supplemental Figure 4A).