AD pathogenesis is characterised by the extensive formation of Aβ plaques, neurofibrillary tangles (NFTs) resulting from Tau and hyperphosphorylated Tau (p-Tau) aggregates and vascular amyloid angiopathy (Ramos-Cejudo et al. 2018; Reiss et al. 2018; Solis et al. 2020). Here, MAPT is linked to Alzheimer disease.