SULF1 and Alzheimer disease: The extracellular sulfatases SULF1 and SULF2, encoded by SULF1 and SULF2, respectively, were also investigated with findings suggesting the HS moieties binding to Aβ contained 6-O-sulfation, further highlighting the involvement of HSPGs and HS biosynthesis in AD (McMillan et al. 2023).