Furthermore,it should be highlighted that in addition to HUP-46 beinga more effective modulator of PP2A activity compared to the correspondingoxazole HUP-55, it is also a more potent modulator of PP2A activity.As HUP-46 is also a brain-penetrating compound, it isa useful molecular probe for the development of therapeutic compoundsfor neurodegenerative diseases. This evidence concerns the gene PTPA and neurodegenerative disease.