found that NTN4 can cooperate with ITGB4 to induce activation of the PI3K‐AKT‐mTOR signalling pathway, which increases phosphorylation levels of AKT and mTOR, thereby protecting cells from TMZ‐induced cellular senescence and enhancing the drug resistance of GBM cells to TMZ. Here, NTN4 is linked to glioblastoma.