For EFS and OS, the greatest associations of TP53 CPVs were observed in patients with ERMS (EFS: AHR, 4.43 [95% CI, 1.79-10.96]; P = .001; OS: AHR, 5.26 [95% CI, 1.92-14.41]; P = .001). The gene discussed is TP53; the disease is embryonal rhabdomyosarcoma.