A wide spectrum of pathogenic variants in NF1 is associated with neurofibromatosis type 1, an autosomal-dominant disorder in which 0.5% to 1.0% of patients develop RMS.24 There is consensus that survival of these individuals is representative of those with non–neurofibromatosis type 1 ERMS,24,25,26 which agrees with our findings. This evidence concerns the gene NF1 and neurofibromatosis type 1.