Knocking out KLF10 not only undid the effect of PDLIM2 on restraining the release of inflammatory factors (TNF‐α, IL‐1β, IL‐6, COX2 and iNOS) from RA‐FLS but also boosted the expression of NF‐κB pathway‐related proteins (p‐IκBα and p‐NF‐κB).126. This evidence concerns the gene TNF and rheumatoid arthritis.