In 2022, Kawata and her colleagues discovered that overexpression KLF4 in IL‐1β stimulated various cells (OA chondrocytes, meniscus cells and synovial cells) resulted in reduced expression levels of IL‐6, MMP3, MMP13 and ADAMTS5, and intra‐articular injection of AAV‐KLF4 led to a reduction in the degree of joint injury and mechanical abnormal pain, and significant improvement in the OA Research Society International (OARSI) score, meniscus histopathology score and synovitis score in mice operated with DMM.84 Here, KLF4 is linked to synovitis.