Same as KLF9, inhibition of KLF10 can eliminate the suppressive effect of PDLIM2 on RA‐FLS, which shows that the activity of FLS is significantly increased, FLS migration is increased, the expression of Bcl‐2 is increased, the expression of apoptosis‐related proteins (Bax, Cyto‐C and Cleaved caspase 3) is decreased, and the expressions of inflammatory factors and MMPs (MMP2 and MMP9) are markedly increased. Here, KLF10 is linked to rheumatoid arthritis.