ABCC8 and brain infarction: Sulfonylurea receptor 1 (SUR1 or ABCC8) is located in brain endothelial cells and can form an ATP sensitive potassium channel (KATP) with Kir6.1 and Kir6.2 subunits.94 Moreover, SUR1 is upregulated after cerebral infarcts and forms a complex with the transient receptor potential melastatin 4 (Trpm4).