Analysis of 48 duodenal adenoma exomes by both MutSigCV and dNdScv showed that somatic mutations in APC and PIGA were significantly overrepresented (q < 0.01) in FAP duodenal adenomas, and APC, PIGA, and KRAS mutations in MAP duodenal adenomas (q < 0.01; Supplementary Table S1). Here, PIGA is linked to Familial adenomatous polyposis.