Although most (12/19) adenomas with PIGA mutations were tubular adenomas (TA) with low-grade dysplasia (LGD), 3/5 adenomas with high-grade dysplasia in the study had PIGA mutations (P = 0.119) as did 4/9 with tubulovillous or villous histology. This evidence concerns the gene PIGA and Takayasu arteritis.