PIGA was not identified as a significantly and recurrently mutated gene in 12 sporadic duodenal adenocarcinomas analyzed by Yuan and colleagues (17), although a different study of 21 sporadic duodenal carcinomas revealed one PIGA variant (p.Q58X; ref. 18), indicating that mutation of PIGA may also be involved in duodenal carcinoma development outside of the context of FAP and MAP. This evidence concerns the gene PIGA and carcinoma of duodenum.