PIGA and Familial adenomatous polyposis: Next, we increased the number of adenoma samples available for somatic mutation analysis by interrogation of WTS data from 22 additional duodenal adenomas for which WES data were unavailable (20 FAP and 2 MAP), identifying three further somatic PIGA mutations, one truncating and two missense, all in FAP adenomas, and further APC and KRAS mutations (Supplementary Table S1).